Mt2

MT-2 — Cyclic Melanocortin Receptor Agonist

MT-2 (Melanotan II) is a synthetic cyclic lactam analog of alpha-melanocyte stimulating hormone (α-MSH). Through structural modifications including cyclization and amino acid substitutions, MT-2 achieves enhanced receptor binding affinity, improved metabolic stability, and broader melanocortin receptor subtype activation compared to the native linear hormone.

Mechanism of Action

MT-2 acts as a non-selective agonist across multiple melanocortin receptor subtypes (MC1R through MC5R). MC1R activation in melanocytes stimulates eumelanin synthesis through the cAMP/PKA/MITF signaling cascade. MC3R and MC4R activation in the hypothalamus modulates appetite, energy homeostasis, and sexual function pathways. The cyclic structure provides superior resistance to enzymatic degradation compared to linear melanocortin peptides.

Research Applications

• Melanogenesis and pigmentation pathway studies
• Melanocortin receptor subtype profiling (MC1R-MC5R)
• Appetite regulation and hypothalamic signaling
• UV-independent melanocyte activation research
• Comparative studies with linear melanocortin analogs

Product Specifications

• Quantity: 10mg per vial
• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Storage: Refrigerate after reconstitution
• Testing: USA lab tested, COA available

For research purposes only. Not for human use or consumption.